The apparent volume of distribution (V/F) of diclofenac potassium is 1.3 L/kg. Diclofenac is more than 99% bound to human serum proteins, primarily to albumin. Serum protein binding is constant over the concentration range (0.15-105 mcg/mL) achieved with recommended doses. Diclofenac diffuses into and out of the synovial fluid. Home chevron_right Drug Comparisons Compare Naproxen vs. Voltaren Head-to-head comparisons of medication uses, side effects, warnings, and more. Naproxen Diclofenac Summary Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works well for treating inflammation and mild to moderate pain. Diclofenac sodium enteric-coated tablets caused fewer digestive (nausea, vomiting, abdominal discomfort) and central nervous system-associated (headache, dizziness) side effects than aspirin or indomethacin [20, 103, 104] and were associated with fewer endoscopically confirmed hemorrhagic and erosive lesions in the GI mucosa than naproxen [104 Naproxen. Doctors recommend a starting dose of 500 mg, then 250 mg every 6–8 hours as necessary. A person should not exceed a daily dose of 1,250 mg. This drug may impact heart, gastrointestinal Medium Dose. High or Max Dose. Celecoxib/Celebrex. 200mg qd. 200mg bid. 200mg bid. COX = cyclo-oxygenase; IR = immediate release; NSAID = nonsteroidal antiinflammatory drug; OA = osteoarthritis; RA = rheumatoid arthritis; SR = sustained release. *. This table does not represent exact or equivalent dosing conversions. A specific type of NSAID, called a selective COX-2 inhibitor, blocks the COX-2 enzyme more than the COX-1 enzyme. The only selective COX-2 NSAID currently available in the United States is the prescription drug celecoxib (Celebrex). Choosing an NSAID The different NSAIDs work similarly, but some people respond better to one than another. If you Results. Efficacy, safety, and tolerability data were found for 146,524 patients in 176 studies included in the NMA. Diclofenac (150 mg/day) was likely to be more effective in alleviating pain than celecoxib (200 mg/day), naproxen (1000 mg/day), and ibuprofen (2400 mg/day), and similar to etoricoxib (60 mg/day); a lower dose of diclofenac (100 mg/day) was comparable to all other treatments in Topical diclofenac appears to have similar benefits in knee osteoarthritis, with fewer gastrointestinal symptoms and potentially less cardiovascular toxicity than oral dosage forms. With the option of topical dosage forms, diclofenac may be a well-suited alternative for people who need to avoid oral medication. 5. Relafen DS (nabumetone) e2jNp.

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